There is a growing body of research that indicates a very strong possibility that the supplement 5-HTP (L-5-Hydroxytryptophan) may be hugely beneficial for a number of problems, but most especially fibromyalgia syndrome (FMS), a chronic pain and fatigue condition.
Fibromyalgia is characterized by several major and minor criteria. The major criteria, of which all three must be met, are:
The minor criteria, of which at least four must be met, are:
There have been several studies published by the Journal of International Medical Research on the effects of 5-HTP on fibromyalgia sufferers. According to one study, "all the clinical parameters studied were significantly improved by treatment with 5-HTP..." Another states that the "overall evaluation of the patient condition assessed by the patient and the investigator indicated a 'good' or 'fair' clinical improvement in nearly 50% of the patients during the treatment period." (Both studies can be accessed through NCBI.)
Many people have found for themselves how effective this herbal supplement can be. It often has been found to be helpful with insomnia, pain and all major fibromyalgia symptoms, including depression. It may also be helpful with obesity, a common 'side problem' related to fibromyalgia due to a general lowering of physical activity.
5-HTP is most commonly extracted from the seeds of the Griffonia plant. It is a substance which, in the body, is easily transformed into serotonin, a chemical that helps to regulate mood and appetite, as well as being necessary in producing melatonin. Tryptophan is a similar chemical, but it is harder for the body to absorb, and is a step further away from serotonin, requiring the body to do more to reach the desired chemical.
There is a strong link between serotonin deficiency and fibromyalgia; some have even claimed that fibromyalgia is in essence nothing more than an overall serotonin deficiency, though that has not been backed up by clinical studies. However, the evidence is nearly overwhelming that raising serotonin levels is at least beneficial for fibromyalgia sufferers.
The usual recommended dose of 5-HTP to try to help with fibromyalgia is 300 mg per day, usually in 3 100 mg doses, but as with any such substance, you should consult with a medical professional before you begin a treatment including it.